The Goldberg brothers are estranged. Matthew Goldberg is a former child prodigy pianist whose performance career, marriage, and financial situation have suddenly deteriorated. As the story opens, he suffers a nervous breakdown during a concert. Simon Goldberg is a long-suffering academic who has dedicated his life to translating and chronicling in obscurity the 16th century Tzvat Circle of Kaballist poets. Having recently found unexpected success with the publication of his book, Simon has left Manhattan and bought a winery in the north of Israel.
Out of money, with nowhere else to go, Matthew reluctantly joins Simon on the winery. There, in the remote splendor of the Ramat HaGolan, the two brothers must confront both their long-simmering animosity as well as their mutual attraction to Einav — the viticulturist who happens to be Simon's new girlfriend.
A story of two brothers, Goldberg Variations is also a film about wine-making, classical music, and the mysteries of Jewish mysticism.